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High Quality NMR Solvents , Deuterated Solvents,Labelled Isotopes By SYNMR Chemicals- Long-range deuterium isotope effects on fluorine-19 -Deuterium as a substituent

NMR Solvents , Deuterated Solvents,Labelled Isotopes By SYNMR Chemicals

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Long-range deuterium isotope effectson fluorine-19 chemical shifts of 4-substituted bicyclo[2.2.2]octyl- and bicyclo[2.2.1]heptyl-1-fluorides :Deuterium as a substituent

Abstract

2H/1H isotope effects on the 19F chemical shifts of 4-substituted bicyclo[2.2.2]oct-1-yl and bicyclo[2.2.1]hept-1-yl fluoride are significantly shielding and deshielding, respectively. This result is consistent with deuterium being viewed as an electronegative substituent relative to hydrogen when attached to an sp3 hybridised carbon.

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2H/1H isotope effects on the 19F chemical shifts of 4-substituted bicyclo[2.2.2]oct-1-yl and bicyclo[2.2.1]hept-1-yl fluoride are significantly shielding and deshielding, respectively. This result is consistent with deuterium being viewed as an electronegative substituent relative to hydrogen when attached to an sp3 hybridised carbon.

NMR Solvents , Deuterated Solvents,Labelled Isotopes By SYNMR Chemicals

Visit www.synmr.in for more

2H/1H isotope effects on the 19F chemical shifts of 4-substituted bicyclo[2.2.2]oct-1-yl and bicyclo[2.2.1]hept-1-yl fluoride are significantly shielding and deshielding, respectively. This result is consistent with deuterium being viewed as an electronegative substituent relative to hydrogen when attached to an sp3 hybridised carbon.

NMR Solvents , Deuterated Solvents,Labelled Isotopes By SYNMR Chemicals

Visit www.synmr.in for more

2H/1H isotope effects on the 19F chemical shifts of 4-substituted bicyclo[2.2.2]oct-1-yl and bicyclo[2.2.1]hept-1-yl fluoride are significantly shielding and deshielding, respectively. This result is consistent with deuterium being viewed as an electronegative substituent relative to hydrogen when attached to an sp3 hybridised carbon.

NMR Solvents , Deuterated Solvents,Labelled Isotopes By SYNMR Chemicals

Visit www.synmr.in for more

The author Dr.Sankar Iyer is Director of Synmr Chemicals Pvt Ltd and is spearheading the technical team of SYNMR. sankar@synmr.in ; www.synmr.in

A well known name in the higher echelons of all big pharma companies,Dr Iyer has over 40 years of experience in Production and R&D.
He was earlier with Merck (USA), CSIRO (Australia), Tata Pharma (Merind), Hikal Ltd (India) and Strides Arcolabs Ltd (India).

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